Pittsburgh vs. Virginia odds, line, spread: 2021 college football picks, Week 12 predictions from proven model

The Virginia Cavaliers and the Pittsburgh Panthers will face off in an ACC clash at 3:30 p.m. ET on Saturday, November 20 at Heinz Field in Pittsburgh. Pitt is 8-2 overall and 4-2 at home, while the Cavaliers are 6-4 overall and 2-2 on the road. It’s a battle for first place in the ACC Coastal division and leading into the game everybody is keeping a close eye on the status of Virginia quarterback Brennan Armstrong. Armstrong missed last week’s game with a rib injury, but Pitt head coach Pat Narduzzi says he is preparing for Armstrong to play and a high-profile QB battle against Kenny Pickett could make for one of the most exciting matchups of the week. 

Pitt is favored by 14.5 points in the latest Pittsburgh vs. Virginia odds from Caesars Sportsbook, and the over-under is set at 66. Before making any Virginia vs. Pittsburgh picks, you’ll want to see the college football predictions and betting advice from the red-hot model at SportsLine.

The SportsLine Projection Model simulates every FBS college football game 10,000 times. Over the past five-plus years, the proprietary computer model has generated a stunning profit of almost $3,500 for $100 players on its top-rated college football picks against the spread. It also enters Week 12 of the 2021 season on a 36-23 run on all top-rated college football side picks. Anyone who has followed it has seen huge returns.

Now, the model has set its sights on Pittsburgh vs. Virginia and it just locked in its coveted CFB picks and predictions. You can head to SportsLine now to see its picks. Here are several college football odds and betting lines for Pittsburgh vs. Virginia:

  • Pittsburgh vs. Virginia spread: Pittsburgh -14.5
  • Pittsburgh vs. Virginia over-under: 66 points

Featured Game | Pittsburgh Panthers vs. Virginia Cavaliers

What you need to know about Pittsburgh

It may have taken overtime to finish the job, but Pitt ultimately got the result they were hoping for on Thursday with a 30-23 win over the North Carolina Tar Heels. It was another big night for Pitt’s QB Kenny Pickett, who passed for three TDs and 347 yards on 44 attempts.

After three relatively average seasons as the starter at Pitt, Pickett has taken his game to another level and his in the thick of the Heisman Trophy conversation with 3,517 passing and 32 touchdowns against just four interceptions while adding 223 yards and four more scores on the ground. He should be in for another big day against a Virginia defense that has given up 1,627 yards and 134 points the last three weeks.

What you need to know about Virginia

Meanwhile, a victory for Virginia just wasn’t in the stars on Saturday as the squad never even grasped a temporary lead. They suffered a grim 28-3 defeat to the Notre Dame Fighting Irish. Quarterback Jay Woolfolk struggled with Brennan Armstrong out, throwing for just 196 yards and two interceptions.

However, we know that Virginia’s passing attack can be devastating if Armstrong is healthy enough to play. The second-year starter has thrown for 3,557 yards and 27 touchdowns against eight interceptions in nine games this season and he’s also mobile enough to cause issues with his legs, rushing for 271 yards and seven scores in 2021.

How to make Pittsburgh vs. Virginia picks

The model has simulated Pittsburgh vs. Virginia 10,000 times and the results are in. We can tell you that the model is leaning under on the point total and it’s also generated a point-spread pick that is hitting in well over 50 percent of simulations. You can only see the model’s Pitt vs. Virginia pick at SportsLine.

So who wins Virginia vs. Pittsburgh? And which side of the spread hits well over 50 percent of the time? Visit SportsLine now to see which side of the spread you need to be all over, all from the model that has crushed its college football picks, and find out.

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